What Is MOTS-c? Mitochondrial Peptide Research Guide

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA. It is studied as a signalling molecule that appears to communicate between the mitochondria and the nucleus.

Research use only. This material is supplied for in-vitro laboratory research. It is not a medicine and is not for human or veterinary consumption, administration, or therapeutic use.

In published research MOTS-c is associated with activation of the AMPK energy-sensing pathway and with influences on glucose metabolism, insulin sensitivity and metabolic homeostasis in cell and animal models. It has also been examined in the context of exercise physiology and metabolic adaptation.

The MOTS-c literature is largely preclinical (cell-culture and rodent models), with limited human data. MOTS-c is not approved as a medicine by the MHRA or any other regulator and is supplied for laboratory research only.

As a lyophilised (freeze-dried) peptide it is typically stored frozen and reconstituted with bacteriostatic water for in-vitro work — see our reconstitution guide and storage guide. Identity and purity should be verified against a batch-matched Certificate of Analysis (COA) with HPLC and mass-spectrometry data. View mots-c product details and COA.

MOTS-c is supplied strictly for in-vitro laboratory research use only. The peer-reviewed references below are provided for research context and do not imply that the compound is safe or effective for use in humans.

1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454. View source